coiA protein (Streptococcus mitis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

coiA

Competence protein CoiA. (317 aa)

Predicted Functional Partners:

dprA

0.858

prsA-2

0.845

pepF

0.841

smi_0982

0.835

recA

0.797

comFA

0.773

ssbA

0.759

smi_0213

0.754

ezrA

0.744

ssbB

0.740

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
coiA	comFA	smi_0980	smi_2058	Competence protein CoiA.	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	0.773
coiA	dprA	smi_0980	smi_1223	Competence protein CoiA.	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	0.858
coiA	ezrA	smi_0980	smi_0861	Competence protein CoiA.	Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.	0.744
coiA	pepF	smi_0980	smi_0981	Competence protein CoiA.	Oligoendopeptidase F.	0.841
coiA	prsA-2	smi_0980	smi_0983	Competence protein CoiA.	Peptidylprolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins.	0.845
coiA	recA	smi_0980	smi_1839	Competence protein CoiA.	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.797
coiA	smi_0213	smi_0980	smi_0213	Competence protein CoiA.	Conserved hypothetical protein.	0.754
coiA	smi_0982	smi_0980	smi_0982	Competence protein CoiA.	COG4122, predicted O-methyltransferase.	0.835
coiA	ssbA	smi_0980	smi_1522	Competence protein CoiA.	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.759
coiA	ssbB	smi_0980	smi_0480	Competence protein CoiA.	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.740
comFA	coiA	smi_2058	smi_0980	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	Competence protein CoiA.	0.773
comFA	dprA	smi_2058	smi_1223	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	0.802
comFA	recA	smi_2058	smi_1839	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.651
comFA	ssbA	smi_2058	smi_1522	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.779
comFA	ssbB	smi_2058	smi_0480	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.792
dprA	coiA	smi_1223	smi_0980	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	Competence protein CoiA.	0.858
dprA	comFA	smi_1223	smi_2058	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	0.802
dprA	recA	smi_1223	smi_1839	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.822
dprA	ssbA	smi_1223	smi_1522	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.862
dprA	ssbB	smi_1223	smi_0480	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.822