Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prsA-2Peptidylprolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (312 aa)    
Predicted Functional Partners:
coiA
Competence protein CoiA.
 
     0.845
pepF
Oligoendopeptidase F.
       0.757
smi_0982
COG4122, predicted O-methyltransferase.
       0.757
smi_1300
Conserved hypothetical protein; Cd00189, tetratricopeptide repeat domain.
 
     0.708
smi_0753
Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; COG1368.
 
     0.695
smi_0362
ABC transporter membrane-spanning permease.
 
   
 0.653
alaRS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
  
  
 0.637
smi_0213
Conserved hypothetical protein.
  
     0.629
smi_1511
Membrane protein involved in production of polysaccharide; COG2244.
 
     0.610
ezrA
Negative regulator of septation ring formation; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family.
  
     0.609
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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