Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_1023PTS system, IIB component; COG3414, SgaB, galactitol-specific IIB. (101 aa)    
Predicted Functional Partners:
smi_1022
COG1762, PtsN, mannitol/fructose-specific IIA domain.
 
 
 0.993
smi_1024
COG3775, GatC, galactitol-specific IIC component.
 
 
 0.992
ptsH
Phosphocarrier protein HPr.
    
  0.902
lacD
Tagatose 1,6-diphosphate aldolase; Belongs to the aldolase LacD family.
 
     0.734
lacB
Galactose-6-phosphate isomerase, LacB subunit.
 
     0.714
smi_1025
LacX; COG2017, GalM, galactose mutarotase and related enzymes.
  
    0.658
lacA
Galactose-6-phosphate isomerase, LacA subunit.
 
     0.645
lacC
Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
 
   
 0.626
fruA
PTS system, fructose specific IIBC component.
  
  
 0.540
smi_1030
Galactose-6-phosphate isomerase, LacB subunit; COG0698, RpiB, ribose 5-phosphate isomerase RpiB.
 
     0.468
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
Server load: medium (46%) [HD]