| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| agaS | lacA | smi_0084 | smi_1026 | Tagatose-6-phosphate ketose/aldose isomerase. | Galactose-6-phosphate isomerase, LacA subunit. | 0.900 |
| agaS | lacB | smi_0084 | smi_1027 | Tagatose-6-phosphate ketose/aldose isomerase. | Galactose-6-phosphate isomerase, LacB subunit. | 0.900 |
| agaS | lacC | smi_0084 | smi_1028 | Tagatose-6-phosphate ketose/aldose isomerase. | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.963 |
| agaS | lacD | smi_0084 | smi_1029 | Tagatose-6-phosphate ketose/aldose isomerase. | Tagatose 1,6-diphosphate aldolase; Belongs to the aldolase LacD family. | 0.815 |
| agaS | pfkA | smi_0084 | smi_1004 | Tagatose-6-phosphate ketose/aldose isomerase. | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.902 |
| agaS | smi_1023 | smi_0084 | smi_1023 | Tagatose-6-phosphate ketose/aldose isomerase. | PTS system, IIB component; COG3414, SgaB, galactitol-specific IIB. | 0.446 |
| codY | lacD | smi_0687 | smi_1029 | GTP-sensing transcriptional pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | Tagatose 1,6-diphosphate aldolase; Belongs to the aldolase LacD family. | 0.724 |
| lacA | agaS | smi_1026 | smi_0084 | Galactose-6-phosphate isomerase, LacA subunit. | Tagatose-6-phosphate ketose/aldose isomerase. | 0.900 |
| lacA | lacB | smi_1026 | smi_1027 | Galactose-6-phosphate isomerase, LacA subunit. | Galactose-6-phosphate isomerase, LacB subunit. | 0.999 |
| lacA | lacC | smi_1026 | smi_1028 | Galactose-6-phosphate isomerase, LacA subunit. | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.994 |
| lacA | lacD | smi_1026 | smi_1029 | Galactose-6-phosphate isomerase, LacA subunit. | Tagatose 1,6-diphosphate aldolase; Belongs to the aldolase LacD family. | 0.918 |
| lacA | lacE | smi_1026 | smi_1038 | Galactose-6-phosphate isomerase, LacA subunit. | PTS system, lactose-specific IIBC component. | 0.790 |
| lacA | lacF | smi_1026 | smi_1037 | Galactose-6-phosphate isomerase, LacA subunit. | PTS system, lactose-specific IIA component. | 0.743 |
| lacA | pfkA | smi_1026 | smi_1004 | Galactose-6-phosphate isomerase, LacA subunit. | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.910 |
| lacA | smi_1023 | smi_1026 | smi_1023 | Galactose-6-phosphate isomerase, LacA subunit. | PTS system, IIB component; COG3414, SgaB, galactitol-specific IIB. | 0.645 |
| lacA | smi_1025 | smi_1026 | smi_1025 | Galactose-6-phosphate isomerase, LacA subunit. | LacX; COG2017, GalM, galactose mutarotase and related enzymes. | 0.706 |
| lacB | agaS | smi_1027 | smi_0084 | Galactose-6-phosphate isomerase, LacB subunit. | Tagatose-6-phosphate ketose/aldose isomerase. | 0.900 |
| lacB | lacA | smi_1027 | smi_1026 | Galactose-6-phosphate isomerase, LacB subunit. | Galactose-6-phosphate isomerase, LacA subunit. | 0.999 |
| lacB | lacC | smi_1027 | smi_1028 | Galactose-6-phosphate isomerase, LacB subunit. | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.996 |
| lacB | lacD | smi_1027 | smi_1029 | Galactose-6-phosphate isomerase, LacB subunit. | Tagatose 1,6-diphosphate aldolase; Belongs to the aldolase LacD family. | 0.964 |