| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| agaS | lacA | smi_0084 | smi_1026 | Tagatose-6-phosphate ketose/aldose isomerase. | Galactose-6-phosphate isomerase, LacA subunit. | 0.900 |
| agaS | lacB | smi_0084 | smi_1027 | Tagatose-6-phosphate ketose/aldose isomerase. | Galactose-6-phosphate isomerase, LacB subunit. | 0.900 |
| agaS | lacC | smi_0084 | smi_1028 | Tagatose-6-phosphate ketose/aldose isomerase. | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.963 |
| agaS | pfkA | smi_0084 | smi_1004 | Tagatose-6-phosphate ketose/aldose isomerase. | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.902 |
| agaS | smi_1030 | smi_0084 | smi_1030 | Tagatose-6-phosphate ketose/aldose isomerase. | Galactose-6-phosphate isomerase, LacB subunit; COG0698, RpiB, ribose 5-phosphate isomerase RpiB. | 0.900 |
| agaS | smi_1031 | smi_0084 | smi_1031 | Tagatose-6-phosphate ketose/aldose isomerase. | Galactose-6-phosphate isomerase, LacA subunit; COG0698, RpiB, ribose 5-phosphate isomerase RpiB. | 0.900 |
| glyA | lacB | smi_1123 | smi_1027 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Galactose-6-phosphate isomerase, LacB subunit. | 0.904 |
| glyA | smi_1030 | smi_1123 | smi_1030 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Galactose-6-phosphate isomerase, LacB subunit; COG0698, RpiB, ribose 5-phosphate isomerase RpiB. | 0.497 |
| lacA | agaS | smi_1026 | smi_0084 | Galactose-6-phosphate isomerase, LacA subunit. | Tagatose-6-phosphate ketose/aldose isomerase. | 0.900 |
| lacA | lacB | smi_1026 | smi_1027 | Galactose-6-phosphate isomerase, LacA subunit. | Galactose-6-phosphate isomerase, LacB subunit. | 0.999 |
| lacA | lacC | smi_1026 | smi_1028 | Galactose-6-phosphate isomerase, LacA subunit. | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. | 0.994 |
| lacA | lacE | smi_1026 | smi_1038 | Galactose-6-phosphate isomerase, LacA subunit. | PTS system, lactose-specific IIBC component. | 0.790 |
| lacA | lacG | smi_1026 | smi_1039 | Galactose-6-phosphate isomerase, LacA subunit. | 6-phospho-beta-galactosidase; Belongs to the glycosyl hydrolase 1 family. | 0.922 |
| lacA | pfkA | smi_1026 | smi_1004 | Galactose-6-phosphate isomerase, LacA subunit. | 6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.910 |
| lacA | smi_1030 | smi_1026 | smi_1030 | Galactose-6-phosphate isomerase, LacA subunit. | Galactose-6-phosphate isomerase, LacB subunit; COG0698, RpiB, ribose 5-phosphate isomerase RpiB. | 0.976 |
| lacA | smi_1031 | smi_1026 | smi_1031 | Galactose-6-phosphate isomerase, LacA subunit. | Galactose-6-phosphate isomerase, LacA subunit; COG0698, RpiB, ribose 5-phosphate isomerase RpiB. | 0.907 |
| lacA | smi_1483 | smi_1026 | smi_1483 | Galactose-6-phosphate isomerase, LacA subunit. | Conserved hypothetical protein; Belongs to the UPF0340 family. | 0.536 |
| lacB | agaS | smi_1027 | smi_0084 | Galactose-6-phosphate isomerase, LacB subunit. | Tagatose-6-phosphate ketose/aldose isomerase. | 0.900 |
| lacB | glyA | smi_1027 | smi_1123 | Galactose-6-phosphate isomerase, LacB subunit. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.904 |
| lacB | lacA | smi_1027 | smi_1026 | Galactose-6-phosphate isomerase, LacB subunit. | Galactose-6-phosphate isomerase, LacA subunit. | 0.999 |