Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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ptsIPhosphoenolpyruvate-protein phosphotransferase, PTS enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (577 aa)    
Predicted Functional Partners:
ptsH
Phosphocarrier protein HPr.
 
 0.999
ptsG
PTS glucose-specific enzyme IIABC component.
 
 0.984
smi_1615
PTS system; COG1263.
 
 0.973
fruA
PTS system, fructose specific IIBC component.
 
  
 0.954
hpr
Hpr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...]
 
   
 0.829
nrdH
Glutaredoxin-like protein.
  
    0.620
lacE
PTS system, lactose-specific IIBC component.
     
 0.560
manL
Phosphotransferase system, mannose-specific EIIAB.
  
  
 0.547
fruB
Fructose-1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
 
  
 0.521
lacT
Transcription antiterminator LacT.
 
 
 
 0.503
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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