Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_1047Conserved hypothetical protein. (164 aa)    
Predicted Functional Partners:
smi_2022
Conserved hypothetical protein.
 
     0.704
smi_1048
Conserved hypothetical protein.
       0.542
smi_1208
Conserved hypothetical protein; COG0561, predicted hydrolases of the HAD superfamily.
 
     0.541
smi_1054
Hydrolase, haloacid dehalogenase-like family; COG1011.
 
     0.518
ptsH
Phosphocarrier protein HPr.
       0.489
ptsI
Phosphoenolpyruvate-protein phosphotransferase, PTS enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
       0.489
ftsY
Cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).
       0.461
smi_1207
Conserved hypothetical protein; COG0561, predicted hydrolases of the HAD superfamily.
       0.461
rexA
Exonuclease RexA; ATP-dependent DNA helicase.
       0.422
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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