smi_1054 protein (Streptococcus mitis) - STRING interaction network

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Score

smi_1054

Hydrolase, haloacid dehalogenase-like family; COG1011. (230 aa)

Predicted Functional Partners:

udK

0.923

comEB

0.909

smi_1908

0.907

upp

0.906

thyA

0.906

tdk

0.905

tmk

0.902

dut

0.901

pyrF

0.901

cmk

0.900

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cmk	comEB	smi_0672	smi_1420	Cytidylate kinase.	dCMP deaminase.	0.901
cmk	pyrF	smi_0672	smi_1446	Cytidylate kinase.	Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	0.614
cmk	smi_1054	smi_0672	smi_1054	Cytidylate kinase.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.900
cmk	smi_1908	smi_0672	smi_1908	Cytidylate kinase.	Conserved hypothetical protein; Pfam00485, PRK, phosphoribulokinase / uridine kinase family.	0.913
cmk	udK	smi_0672	smi_1013	Cytidylate kinase.	Uridine kinase.	0.945
cmk	upp	smi_0672	smi_1418	Cytidylate kinase.	Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.	0.654
comEB	cmk	smi_1420	smi_0672	dCMP deaminase.	Cytidylate kinase.	0.901
comEB	dut	smi_1420	smi_0026	dCMP deaminase.	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.927
comEB	smi_1054	smi_1420	smi_1054	dCMP deaminase.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.909
comEB	tdk	smi_1420	smi_1129	dCMP deaminase.	Thymidine kinase.	0.917
comEB	thyA	smi_1420	smi_1477	dCMP deaminase.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.921
comEB	tmk	smi_1420	smi_0938	dCMP deaminase.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.913
comEB	udK	smi_1420	smi_1013	dCMP deaminase.	Uridine kinase.	0.517
dut	comEB	smi_0026	smi_1420	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	dCMP deaminase.	0.927
dut	smi_1054	smi_0026	smi_1054	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.901
dut	tdk	smi_0026	smi_1129	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidine kinase.	0.951
dut	thyA	smi_0026	smi_1477	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.953
dut	tmk	smi_0026	smi_0938	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.944
pyrF	cmk	smi_1446	smi_0672	Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Cytidylate kinase.	0.614
pyrF	smi_1054	smi_1446	smi_1054	Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.901