Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1073COG0745, OmpR, response regulator. (233 aa)    
Predicted Functional Partners:
smi_1072
Histidine kinase; COG0642, signal transduction histidine kinase.
 
   0.955
smi_0093
Histidine kinase.
 
 
 0.819
smi_1176
Histidine kinase; COG5002, VicK, signal transduction histidine kinase.
 
 0.790
ciaH
Sensor protein CiaH histidine kinase.
 
   0.782
smi_0650
Histidine kinase.
 
 
 0.744
smi_1485
Response regulator; COG4753.
  
     0.616
smi_0309
Histidine kinase.
 
 
 0.572
vncS
Histidine kinase.
 
 
 0.567
smi_1074
Conserved hypothetical protein; Cd02432, Nodulin-21_like_1.
       0.516
rpoD
DNA-dependent RNA Polymerase sigma factor rpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
   
 
 0.456
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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