Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_1080Conserved hypothetical protein; Belongs to the SprT family. (149 aa)    
Predicted Functional Partners:
smi_1081
COG2183, Tex, transcriptional accessory protein.
  
  
 0.880
smi_1079
Conserved hypothetical protein; COG1983, stress-responsive transcriptional regulator.
       0.769
smi_0940
Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
     0.695
smi_1085
Conserved hypothetical protein; COG3689, predicted membrane protein.
 
     0.658
smi_0316
Conserved hypothetical protein; COG3480, SdrC, predicted secreted protein containing a PDZ domain.
 
     0.647
smi_1755
Conserved hypothetical protein; Belongs to the UPF0398 family.
  
     0.592
smi_1639
Conserved hypothetical protein; COG1161, predicted GTPase.
  
     0.554
smi_1084
Conserved hypothetical protein; COG0701, predicted permease.
 
     0.552
hpr
Hpr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...]
 
     0.526
smi_0818
Conserved hypothetical protein.
  
     0.477
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.