tdk protein (Streptococcus mitis) - STRING interaction network

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[Homology]

Score

tdk

Thymidine kinase. (199 aa)

Predicted Functional Partners:

thyA

0.971

deoA

0.952

dut

0.951

prfA

0.945

tmk

0.938

comEB

0.917

cdd

0.910

hemK

0.909

smi_1054

0.905

smi_1125

0.870

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cdd	deoA	smi_0891	smi_0889	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	COG0213, DeoA, thymidine phosphorylase.	0.991
cdd	smi_1054	smi_0891	smi_1054	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.900
cdd	tdk	smi_0891	smi_1129	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	Thymidine kinase.	0.910
comEB	deoA	smi_1420	smi_0889	dCMP deaminase.	COG0213, DeoA, thymidine phosphorylase.	0.510
comEB	dut	smi_1420	smi_0026	dCMP deaminase.	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.927
comEB	smi_1054	smi_1420	smi_1054	dCMP deaminase.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.909
comEB	tdk	smi_1420	smi_1129	dCMP deaminase.	Thymidine kinase.	0.917
comEB	thyA	smi_1420	smi_1477	dCMP deaminase.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.921
comEB	tmk	smi_1420	smi_0938	dCMP deaminase.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.913
deoA	cdd	smi_0889	smi_0891	COG0213, DeoA, thymidine phosphorylase.	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.	0.991
deoA	comEB	smi_0889	smi_1420	COG0213, DeoA, thymidine phosphorylase.	dCMP deaminase.	0.510
deoA	smi_1054	smi_0889	smi_1054	COG0213, DeoA, thymidine phosphorylase.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.900
deoA	tdk	smi_0889	smi_1129	COG0213, DeoA, thymidine phosphorylase.	Thymidine kinase.	0.952
dut	comEB	smi_0026	smi_1420	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	dCMP deaminase.	0.927
dut	smi_1054	smi_0026	smi_1054	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Hydrolase, haloacid dehalogenase-like family; COG1011.	0.901
dut	tdk	smi_0026	smi_1129	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidine kinase.	0.951
dut	thyA	smi_0026	smi_1477	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.	0.953
dut	tmk	smi_0026	smi_0938	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.	0.944
hemK	prfA	smi_1126	smi_1127	Protoporphyrinogen oxidase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.	Peptide chain release factor I; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	0.995
hemK	smi_1125	smi_1126	smi_1125	Protoporphyrinogen oxidase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.	Conserved hypothetical protein; COG0009, translation factor (SUA5); Belongs to the SUA5 family.	0.949