Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1155Conserved hypothetical protein; COG4109, predicted transcriptional regulator containing CBS domains. (425 aa)    
Predicted Functional Partners:
smi_1156
Acetyltransferase, GNAT family; COG1670, acetyltransferases, including N-acetylases of ribosomal proteins.
       0.865
map
Methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
       0.847
murZ
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
       0.847
smi_1743
Conserved hypothetical protein; COG4758, membrane protein.
  
     0.730
smi_2070
Conserved hypothetical protein.
  
   
 0.679
smi_1920
Conserved hypothetical protein; Belongs to the UPF0297 family.
      
 0.613
smi_1990
Conserved hypothetical protein; Cd01518, rhodanese homology domain superfamily; Belongs to the UPF0176 family.
      
 0.599
smi_0377
Nucleic-acid-binding protein implicated in transcription termination.
      
 0.553
smi_1742
Histidine kinase; COG4585.
  
     0.491
tnpA-30
Transposase, ISSmi1; COG2826, IS30 family.
       0.461
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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