Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
smi_1176Histidine kinase; COG5002, VicK, signal transduction histidine kinase. (449 aa)    
Predicted Functional Partners:
smi_1177
COG0745, response regulator, OmpR family.
 0.998
smi_1485
Response regulator; COG4753.
     0.941
vicX
Conserved protein VicX; Pfam00753, metallo-beta-lactamase superfamily.
  
  
 0.874
smi_0092
DNA-binding response regulator.
 
 
 0.820
smi_1073
COG0745, OmpR, response regulator.
 
 0.790
smi_0308
Response regulator.
 
 
 0.781
smi_0649
DNA-binding response regulator.
 
 
 0.777
ciaR
Transcriptional regulatory protein.
 
 0.676
smi_1749
Response regulator; COG0745, ompR family.
 
 
 0.620
vncR
DNA-binding response regulator.
 
 
 0.595
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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