smi_1178 protein (Streptococcus mitis) - STRING interaction network

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smi_1178

A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (393 aa)

Predicted Functional Partners:

exoA

0.923

dnaN

0.807

smi_1177

0.714

aspS

0.706

vicX

0.696

mutM

0.689

pta

0.661

smi_1183

0.634

rluA3

0.633

nadK

0.629

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aspS	smi_1178	smi_0127	smi_1178	aspartyl-tRNA synthetase (aspartate-tRNA ligase); Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.706
dnaN	exoA	smi_0002	smi_0530	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	Exodeoxyribonuclease III.	0.936
dnaN	smi_1178	smi_0002	smi_1178	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.807
exoA	dnaN	smi_0530	smi_0002	Exodeoxyribonuclease III.	DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]	0.936
exoA	smi_1178	smi_0530	smi_1178	Exodeoxyribonuclease III.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.923
mutM	smi_1178	smi_0971	smi_1178	formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.689
nadK	pta	smi_1181	smi_1179	Inorganic polyphosphate ADP/NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Phosphotransacetylase; COG0280.	0.903
nadK	rluA3	smi_1181	smi_1180	Inorganic polyphosphate ADP/NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	0.873
nadK	smi_1178	smi_1181	smi_1178	Inorganic polyphosphate ADP/NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.629
nadK	smi_1183	smi_1181	smi_1183	Inorganic polyphosphate ADP/NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	Conserved hypothetical protein; COG4116, uncharacterized protein.	0.800
pta	nadK	smi_1179	smi_1181	Phosphotransacetylase; COG0280.	Inorganic polyphosphate ADP/NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.903
pta	rluA3	smi_1179	smi_1180	Phosphotransacetylase; COG0280.	23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	0.793
pta	smi_1178	smi_1179	smi_1178	Phosphotransacetylase; COG0280.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.661
pta	smi_1183	smi_1179	smi_1183	Phosphotransacetylase; COG0280.	Conserved hypothetical protein; COG4116, uncharacterized protein.	0.548
rluA3	nadK	smi_1180	smi_1181	23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	Inorganic polyphosphate ADP/NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.873
rluA3	pta	smi_1180	smi_1179	23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	Phosphotransacetylase; COG0280.	0.793
rluA3	smi_1178	smi_1180	smi_1178	23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.633
rluA3	smi_1183	smi_1180	smi_1183	23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.	Conserved hypothetical protein; COG4116, uncharacterized protein.	0.733
smi_1177	smi_1178	smi_1177	smi_1178	COG0745, response regulator, OmpR family.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.714
smi_1177	vicX	smi_1177	smi_1175	COG0745, response regulator, OmpR family.	Conserved protein VicX; Pfam00753, metallo-beta-lactamase superfamily.	0.958