radC protein (Streptococcus mitis) - STRING interaction network

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radC

DNA repair protein RadC; COG2003; Belongs to the UPF0758 family. (226 aa)

Predicted Functional Partners:

mreC

0.800

comFA

0.764

cinA

0.747

dprA

0.672

pcrA

0.671

dut

0.639

RadA

0.607

celA

0.594

celB

0.570

hexB

0.564

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RadA	dprA	smi_0028	smi_1223	DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	0.495
RadA	dut	smi_0028	smi_0026	DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.859
RadA	hexB	smi_0028	smi_1931	DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	DNA mismatch repair protein hexB; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.429
RadA	pcrA	smi_0028	smi_1191	DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	ATP-dependent DNA helicase PcrA.	0.424
RadA	radC	smi_0028	smi_1190	DNA repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.	DNA repair protein RadC; COG2003; Belongs to the UPF0758 family.	0.607
celA	celB	smi_0955	smi_0956	Competence protein CelA.	Competence protein CelB.	0.975
celA	cinA	smi_0955	smi_1840	Competence protein CelA.	Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.	0.630
celA	comFA	smi_0955	smi_2058	Competence protein CelA.	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	0.898
celA	dprA	smi_0955	smi_1223	Competence protein CelA.	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	0.678
celA	radC	smi_0955	smi_1190	Competence protein CelA.	DNA repair protein RadC; COG2003; Belongs to the UPF0758 family.	0.594
celB	celA	smi_0956	smi_0955	Competence protein CelB.	Competence protein CelA.	0.975
celB	cinA	smi_0956	smi_1840	Competence protein CelB.	Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.	0.751
celB	comFA	smi_0956	smi_2058	Competence protein CelB.	Helicase ComFA; COG4098, superfamily II DNA/RNA helicase required for DNA uptake.	0.674
celB	dprA	smi_0956	smi_1223	Competence protein CelB.	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	0.791
celB	radC	smi_0956	smi_1190	Competence protein CelB.	DNA repair protein RadC; COG2003; Belongs to the UPF0758 family.	0.570
cinA	celA	smi_1840	smi_0955	Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.	Competence protein CelA.	0.630
cinA	celB	smi_1840	smi_0956	Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.	Competence protein CelB.	0.751
cinA	dprA	smi_1840	smi_1223	Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.	DNA processing protein DprA; COG0758, predicted Rossmann fold nucleotide-binding protein involved in DNA uptake, Smf family.	0.571
cinA	dut	smi_1840	smi_0026	Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.	Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.	0.443
cinA	hexB	smi_1840	smi_1931	Damage inducible protein CinA; COG1058, CinA, predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.	DNA mismatch repair protein hexB; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.605