Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
smi_1197Conserved hypothetical protein; Pfam02829, 3H domain, three conserved histidine residues. (171 aa)    
Predicted Functional Partners:
smi_1196
Conserved hypothetical protein.
 
   
 0.882
birA
Bifunctional protein, biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.570
smi_1195
Membrane protein; COG4684.
     
 0.455
smi_1194
Flavoprotein involved in panthothenate metabolism; COG0452, phosphopantothenoylcysteine synthetase/decarboxylase.
       0.446
smi_1193
Flavoprotein; Pfam04127, DNA / pantothenate metabolism flavoprotein.
       0.435
gpmA-2
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (phosphoglyceromutase); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
       0.422
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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