Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1200Acetyltransferase; COG1670. (187 aa)    
Predicted Functional Partners:
smi_1199
Pfam00583, acetyltransferase (GNAT) family.
  
    0.796
uvrB
Excinuclease ABC-subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
       0.792
smi_1124
Conserved hypothetical protein; Pfam00583, acetyltransferase (GNAT) family.
      0.694
smi_1198
Conserved hypothetical protein; COG1051, ADP-ribose pyrophosphatase.
 
    0.631
smi_1202
Conserved hypothetical protein; Pfam02517, CAAX amino terminal protease family.
       0.563
smi_0117
Conserved hypothetical protein.
  
    0.542
smi_1603
Conserved hypothetical protein.
  
    0.479
smi_1470
Transcriptional regulator; COG1396.
  
    0.476
smi_1428
Conserved hypothetical protein.
  
     0.451
smi_0828
Conserved hypothetical protein; COG0596, MhpC, predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily); pfam00561, Abhydrolase_1, alpha/beta hydrolase fold.
  
    0.440
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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