smi_1258 protein (Streptococcus mitis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

smi_1258

Conserved hypothetical protein; COG1437, adenylate cyclase, class 2. (185 aa)

Predicted Functional Partners:

relA

0.900

smi_0848

0.900

smi_1182

0.900

ndk

0.900

nrdD

0.900

sulC

0.800

smi_1259

0.429

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ndk	nrdD	smi_1845	smi_1912	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	0.903
ndk	relA	smi_1845	smi_0642	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.904
ndk	smi_0848	smi_1845	smi_0848	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Hypothetical protein; COG1437, CyaB, adenylate cyclase.	0.900
ndk	smi_1182	smi_1845	smi_1182	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Conserved hypothetical protein.	0.900
ndk	smi_1258	smi_1845	smi_1258	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Conserved hypothetical protein; COG1437, adenylate cyclase, class 2.	0.900
ndk	sulC	smi_1845	smi_0281	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	GTP cyclohydrolase.	0.828
nrdD	ndk	smi_1912	smi_1845	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.903
nrdD	relA	smi_1912	smi_0642	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.908
nrdD	smi_0848	smi_1912	smi_0848	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	Hypothetical protein; COG1437, CyaB, adenylate cyclase.	0.900
nrdD	smi_1182	smi_1912	smi_1182	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	Conserved hypothetical protein.	0.900
nrdD	smi_1258	smi_1912	smi_1258	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	Conserved hypothetical protein; COG1437, adenylate cyclase, class 2.	0.900
nrdD	sulC	smi_1912	smi_0281	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	GTP cyclohydrolase.	0.800
relA	ndk	smi_0642	smi_1845	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.904
relA	nrdD	smi_0642	smi_1912	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	0.908
relA	smi_0848	smi_0642	smi_0848	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Hypothetical protein; COG1437, CyaB, adenylate cyclase.	0.900
relA	smi_1182	smi_0642	smi_1182	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Conserved hypothetical protein.	0.909
relA	smi_1258	smi_0642	smi_1258	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Conserved hypothetical protein; COG1437, adenylate cyclase, class 2.	0.900
relA	sulC	smi_0642	smi_0281	GTP pyrophosphokinase, stringent response protein; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	GTP cyclohydrolase.	0.800
smi_0848	ndk	smi_0848	smi_1845	Hypothetical protein; COG1437, CyaB, adenylate cyclase.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.900
smi_0848	nrdD	smi_0848	smi_1912	Hypothetical protein; COG1437, CyaB, adenylate cyclase.	Anaerobic ribonucleotide reductase; COG1328, NrdD, oxygen-sensitive ribonucleoside-triphosphate reductase.	0.900