| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aroA | aroC | smi_0763 | smi_0758 | 3-enolpyruvylshikimate-5-phosphate synthetase, 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.997 |
| aroA | pheA | smi_0763 | smi_0765 | 3-enolpyruvylshikimate-5-phosphate synthetase, 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Prephenate dehydratase. | 0.892 |
| aroA | smi_0759 | smi_0763 | smi_0759 | 3-enolpyruvylshikimate-5-phosphate synthetase, 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Prephenate dehydrogenase. | 0.993 |
| aroA | smi_1268 | smi_0763 | smi_1268 | 3-enolpyruvylshikimate-5-phosphate synthetase, 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate mutase/prephenate dehydratase; COG1605, Chorismate mutase. | 0.710 |
| aroA | smi_1481 | smi_0763 | smi_1481 | 3-enolpyruvylshikimate-5-phosphate synthetase, 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate binding enzyme para-aminobenzoate synthetase. | 0.523 |
| aroC | aroA | smi_0758 | smi_0763 | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 3-enolpyruvylshikimate-5-phosphate synthetase, 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.997 |
| aroC | pheA | smi_0758 | smi_0765 | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Prephenate dehydratase. | 0.681 |
| aroC | smi_0542 | smi_0758 | smi_0542 | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component II (glutamine amido-transferase). | 0.932 |
| aroC | smi_0759 | smi_0758 | smi_0759 | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Prephenate dehydrogenase. | 0.976 |
| aroC | smi_1268 | smi_0758 | smi_1268 | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase/prephenate dehydratase; COG1605, Chorismate mutase. | 0.958 |
| aroC | smi_1481 | smi_0758 | smi_1481 | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate binding enzyme para-aminobenzoate synthetase. | 0.951 |
| aroC | trpE | smi_0758 | smi_0541 | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.972 |
| crcB1 | crcB2 | smi_1266 | smi_1267 | CrcB protein, paralog 1; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | CrcB protein, paralog 2; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | 0.837 |
| crcB1 | smi_1268 | smi_1266 | smi_1268 | CrcB protein, paralog 1; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | Chorismate mutase/prephenate dehydratase; COG1605, Chorismate mutase. | 0.785 |
| crcB2 | crcB1 | smi_1267 | smi_1266 | CrcB protein, paralog 2; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | CrcB protein, paralog 1; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | 0.837 |
| crcB2 | smi_1268 | smi_1267 | smi_1268 | CrcB protein, paralog 2; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family. | Chorismate mutase/prephenate dehydratase; COG1605, Chorismate mutase. | 0.785 |
| pheA | aroA | smi_0765 | smi_0763 | Prephenate dehydratase. | 3-enolpyruvylshikimate-5-phosphate synthetase, 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.892 |
| pheA | aroC | smi_0765 | smi_0758 | Prephenate dehydratase. | Chorismate synthase, (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.681 |
| pheA | smi_0759 | smi_0765 | smi_0759 | Prephenate dehydratase. | Prephenate dehydrogenase. | 0.988 |
| pheA | smi_1268 | smi_0765 | smi_1268 | Prephenate dehydratase. | Chorismate mutase/prephenate dehydratase; COG1605, Chorismate mutase. | 0.923 |
