Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1292Lysozyme; COG3757, lyzozyme M1 (1,4-beta-N-acetylmuramidase). (266 aa)    
Predicted Functional Partners:
smi_1287
Conserved hypothetical protein.
 
     0.846
smi_1293
Conserved hypothetical protein; COG2035, predicted membrane protein.
 
     0.776
smi_0583
Chromosome replication initiation protein/membrane attachment protein; COG3611.
  
     0.734
smi_1294
Regulatory protein; Pfam04073, prolyl-tRNA synthetases associated domain; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.
       0.732
gpmA
Phosphoglycerate mutase.
       0.732
gcaD
UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
       0.612
smi_1290
Conserved hypothetical protein; Pfam00293, NUDIX domain.
       0.608
smi_1289
Conserved hypothetical protein.
       0.598
lysS
Lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
       0.598
ftsW
Cell division protein FtsW; Belongs to the SEDS family.
 
     0.589
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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