Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_1336Transcriptional regulator, Tn916; Pfam01381, Helix-turn-helix. (117 aa)    
Predicted Functional Partners:
smi_1338
Conserved hypothetical protein; COG1595, DNA-directed RNA polymerase specialized sigma, sigma24 homolog.
 
    0.840
pnpA
Polyribonucleotide nucleotidyltransferase.
 
     0.840
tetM
Tetracycline resistance protein TetM; COG0480, ribosomal protection.
  
     0.765
smi_1332
Cell wall hydrolase, lytic transglycosylase; Pfam00877, NlpC/P60 family, PECACE domain.
  
     0.587
smi_0786
Conserved hypothetical protein; Pfam06970, RepA_N, replication initiator protein A (RepA) N-terminus.
 
     0.543
smi_1320
Conserved hypothetical protein; Pfam06125.
  
     0.480
smi_1337
Conserved hypothetical protein.
       0.470
smi_1331
Transmembrane amino acid transporter protein; Pfam01490.
  
     0.464
smi_1333
Conserved hypothetical protein.
  
     0.432
smi_1321
Conserved hypothetical protein; Pfam06125.
  
     0.404
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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