Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
smi_1346Conserved hypothetical protein. (241 aa)    
Predicted Functional Partners:
smi_1344
Conserved hypothetical protein; Pfam00892, Integral membrane protein.
       0.865
smi_1345
Conserved hypothetical protein; Pfam00144, beta-lactamase.
       0.865
smi_1347
Glycerol uptake facilitator paralog; Cd00333, Major intrinsic protein (MIP) superfamily; Belongs to the MIP/aquaporin (TC 1.A.8) family.
       0.674
pepX
Xaa-Pro dipeptidyl-peptidase; Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline; Belongs to the peptidase S15 family.
       0.425
fni
Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
       0.424
smi_1745
Phosphomevalonate kinase; COG1577.
       0.424
smi_1746
Mevalonate pyrophosphate decarboxylase; COG3407.
       0.424
smi_1747
Mevalonate kinase; COG1577.
       0.424
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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