Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
smi_1351Conserved hypothetical protein. (246 aa)    
Predicted Functional Partners:
smi_1350
Conserved hypothetical protein.
 
     0.966
smi_1352
Hydrolase; COG2819, predicted hydrolase of the alpha/beta superfamily.
 
     0.960
smi_0640
Metallo-beta-lactamase superfamily protein; COG0491, Zn-dependent hydrolases.
 
     0.503
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.497
smi_1354
Pyridoxal-phosphate dependent aminotransferase; COG1104, cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
       0.496
smi_1403
Conserved hypothetical protein; COG3568, metal-dependent hydrolase.
  
     0.495
gid
Gid NAD(FAD)-utilizing enzyme possibly involved in translation; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily.
       0.461
zmpB
Zinc metalloprotease; LPXTG motif.
  
     0.415
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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