Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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Score
smi_1354Pyridoxal-phosphate dependent aminotransferase; COG1104, cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes. (380 aa)    
Predicted Functional Partners:
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
 
 0.996
smi_0918
NifU family protein.
 
 0.972
smi_0638
HesA/MoeB/ThiF family protein.
   
 0.960
smi_1185
Aminotransferase; COG1104, cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
  
  
 
0.917
smi_1355
Conserved hypothetical protein.
       0.730
rlmN
Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family.
  
  
 0.653
thrA
Homoserine dehydrogenase.
   
 
 0.651
smi_1730
HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.
 
 0.548
dnaK
Class I heat-shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.544
smi_1352
Hydrolase; COG2819, predicted hydrolase of the alpha/beta superfamily.
       0.542
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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