Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1376Conserved hypothetical protein; COG2843, enzyme of poly-gamma-glutamate biosynthesis. (439 aa)    
Predicted Functional Partners:
ssrA
tmRNA; Cd00801, bacteriophage P4-like integrase.
     
 0.833
smi_1375
Conserved hypothetical protein; COG0561, predicted hydrolase, HAD superfamily.
       0.833
smi_1492
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
    0.529
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
       0.461
smi_0927
Conserved hypothetical protein.
       0.461
rpmA
50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.
       0.461
thiI
Thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.461
smi_1354
Pyridoxal-phosphate dependent aminotransferase; COG1104, cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
       0.461
smi_0334
Conserved hypothetical protein.
     
 0.445
smi_1287
Conserved hypothetical protein.
  
     0.415
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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