Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pmiMannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family. (314 aa)    
Predicted Functional Partners:
gpi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
 
 
 0.967
smi_1614
Transcriptional regulator/sugar kinase; COG1940.
 
 
 0.960
manL
Phosphotransferase system, mannose-specific EIIAB.
 
  
 0.959
nagB
N-acetylglucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
     
 0.949
manM
Phosphotransferase system, mannose-specific, component IIC.
 
  
  0.934
glmS
Glutamine--fructose-6-phosphate transaminase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
 0.931
pfkA
6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
    
 0.929
manN
Mannose-specific phosphotransferase system component IID.
 
  
  0.928
PTS-EII
Phosphotransferase system sugar-specific EII component.
    
 0.909
PTS-EIIC
PTS system, IIC component.
    
  0.905
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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