Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_1470Transcriptional regulator; COG1396. (301 aa)    
Predicted Functional Partners:
mutR
Transcriptional regulator; Cd00093, helix-turn-helix XRE-family.
  
     0.520
smi_1468
Hypothetical protein.
 
     0.491
smi_1200
Acetyltransferase; COG1670.
  
    0.476
smi_0864
Conserved hypothetical protein; Pfam00293, NUDIX; COG0494, MutT; Belongs to the Nudix hydrolase family.
  
    0.443
smi_1743
Conserved hypothetical protein; COG4758, membrane protein.
  
     0.416
smi_1101
Conserved hypothetical protein; Pfam06414, Zeta toxin.
   
 
 0.412
smi_1469
Hypothetical protein.
       0.405
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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