Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1484Histidine kinase; COG2972. (563 aa)    
Predicted Functional Partners:
smi_1485
Response regulator; COG4753.
 
  
 0.986
smi_1937
COG 4753, two component regulatory system, response regulators containing CheY-like receiver domain and AraC-type DNA-binding domain.
 
 
 0.983
smi_1938
COG2972, sensor histidine kinase, two component regulatory system; signal transduction proteins with a C-terminal ATPase domain.
  
  
 
0.929
smi_1487
Conserved hypothetical protein; COG2143, thioredoxin-related protein.
 
   
 0.862
smi_1939
Conserved hypothetical protein; COG5578, predicted integral membrane proteins.
  
  
 0.632
msrA-2
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
       0.608
ccdA2
Cytochrome c biogenesis protein CcdA; COG0785.
     
 0.605
zmpB
Zinc metalloprotease; LPXTG motif.
       0.536
smi_1483
Conserved hypothetical protein; Belongs to the UPF0340 family.
       0.536
smi_1480
Conserved hypothetical protein.
       0.423
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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