Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1582Conserved hypothetical protein; COG5549, predicted Zn-dependent protease. (233 aa)    
Predicted Functional Partners:
uvrC
Excinuclease, subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
       0.682
smi_1580
Conserved hypothetical protein; COG0622, predicted phosphoesterase.
       0.655
fibB
Peptidoglycan branched peptide synthesis protein, femAB family; COG2348.
       0.588
gtfB
Conserved hypothetical protein; Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to the substrate protein, attaching the first sugar residue. Stabilizes the glycosylation activity of GtfA. Has no N-acetylglucosaminyl transferase activity on its own.
  
     0.569
fibA
Peptidoglycan branched peptide synthesis protein, femAB family; COG2348.
       0.567
smi_1659
Conserved hypothetical protein.
  
     0.560
endA
DNA-entry nuclease (competence-specific nuclease).
 
     0.550
smi_1433
COG4633, uncharacterized protein conserved in bacteria.
  
     0.506
gtfA
Predicted glycosyl transferase, group 1; Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in the substrate protein. Part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon.
  
     0.475
dltD
Membrane-associated protein dltD; Facilitates D-alanine ligation to DCP by binding Dcl and Dcp.
  
     0.468
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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