Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_16183-hydroxy-3-methylglutaryl-coenzyme a reductase; COG1257; Belongs to the HMG-CoA reductase family. (424 aa)    
Predicted Functional Partners:
smi_1619
3-hydroxy-3-methylglutaryl CoA synthase; COG3425.
 
 0.999
smi_1747
Mevalonate kinase; COG1577.
 0.998
smi_1746
Mevalonate pyrophosphate decarboxylase; COG3407.
 
  
 0.904
fni
Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.889
smi_1745
Phosphomevalonate kinase; COG1577.
 
 
 0.879
ispA
Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.726
smi_1620
Conserved hypothetical protein; COG3610.
       0.709
smi_1621
Conserved hypothetical protein; COG2966.
       0.708
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
  
 0.669
smi_1561
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
     
 0.482
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.