smi_1639 protein (Streptococcus mitis) - STRING interaction network

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Score

smi_1639

Conserved hypothetical protein; COG1161, predicted GTPase. (368 aa)

Predicted Functional Partners:

rsfS

0.929

smi_1640

0.926

smi_1638

0.874

rpmD

0.852

rplJ

0.845

nadD

0.845

aroE

0.824

rplX

0.818

smi_1636

0.813

rplD

0.797

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aroE	nadD	smi_0756	smi_1637	Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.715
aroE	rsfS	smi_0756	smi_1634	Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.490
aroE	smi_1636	smi_0756	smi_1636	Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	Conserved hypothetical protein; COG1713, predicted hydrolase.	0.563
aroE	smi_1638	smi_0756	smi_1638	Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	Conserved hypothetical protein.	0.517
aroE	smi_1639	smi_0756	smi_1639	Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	Conserved hypothetical protein; COG1161, predicted GTPase.	0.824
nadD	aroE	smi_1637	smi_0756	Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	0.715
nadD	rsfS	smi_1637	smi_1634	Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.953
nadD	smi_1636	smi_1637	smi_1636	Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Conserved hypothetical protein; COG1713, predicted hydrolase.	0.997
nadD	smi_1638	smi_1637	smi_1638	Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Conserved hypothetical protein.	0.933
nadD	smi_1639	smi_1637	smi_1639	Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Conserved hypothetical protein; COG1161, predicted GTPase.	0.845
nadD	smi_1640	smi_1637	smi_1640	Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Conserved hypothetical protein; COG2179, predicted hydrolase of the HAD superfamily.	0.753
rplD	rplJ	smi_1904	smi_0783	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.	50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	0.989
rplD	rplX	smi_1904	smi_1894	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.	50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.	0.999
rplD	rpmD	smi_1904	smi_1887	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.	50S ribosomal protein L30.	0.998
rplD	rsfS	smi_1904	smi_1634	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.	Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.841
rplD	smi_1639	smi_1904	smi_1639	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.	Conserved hypothetical protein; COG1161, predicted GTPase.	0.797
rplJ	rplD	smi_0783	smi_1904	50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	50S ribosomal protein L4; Forms part of the polypeptide exit tunnel.	0.989
rplJ	rplX	smi_0783	smi_1894	50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.	0.994
rplJ	rpmD	smi_0783	smi_1887	50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	50S ribosomal protein L30.	0.995
rplJ	rsfS	smi_0783	smi_1634	50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.	Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.455