smi_1732 protein (Streptococcus mitis) - STRING interaction network

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smi_1732

Transcriptional regulator; Cd00093, HTH_XRE, helix-turn-helix XRE-family like proteins. (309 aa)

Predicted Functional Partners:

smi_1730

0.485

smi_1731

0.485

grpE-2

0.476

smi_1729

0.476

smi_1727

0.459

smi_1101

0.412

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
grpE-2	smi_1727	smi_1728	smi_1727	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	Conserved hypothetical protein.	0.743
grpE-2	smi_1729	smi_1728	smi_1729	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	0.777
grpE-2	smi_1730	smi_1728	smi_1730	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.	0.978
grpE-2	smi_1731	smi_1728	smi_1731	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	Conserved hypothetical protein.	0.757
grpE-2	smi_1732	smi_1728	smi_1732	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	Transcriptional regulator; Cd00093, HTH_XRE, helix-turn-helix XRE-family like proteins.	0.476
smi_1101	smi_1732	smi_1101	smi_1732	Conserved hypothetical protein; Pfam06414, Zeta toxin.	Transcriptional regulator; Cd00093, HTH_XRE, helix-turn-helix XRE-family like proteins.	0.412
smi_1727	grpE-2	smi_1727	smi_1728	Conserved hypothetical protein.	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	0.743
smi_1727	smi_1729	smi_1727	smi_1729	Conserved hypothetical protein.	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	0.743
smi_1727	smi_1730	smi_1727	smi_1730	Conserved hypothetical protein.	HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.	0.727
smi_1727	smi_1731	smi_1727	smi_1731	Conserved hypothetical protein.	Conserved hypothetical protein.	0.726
smi_1727	smi_1732	smi_1727	smi_1732	Conserved hypothetical protein.	Transcriptional regulator; Cd00093, HTH_XRE, helix-turn-helix XRE-family like proteins.	0.459
smi_1729	grpE-2	smi_1729	smi_1728	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	0.777
smi_1729	smi_1727	smi_1729	smi_1727	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	Conserved hypothetical protein.	0.743
smi_1729	smi_1730	smi_1729	smi_1730	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.	0.761
smi_1729	smi_1731	smi_1729	smi_1731	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	Conserved hypothetical protein.	0.757
smi_1729	smi_1732	smi_1729	smi_1732	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	Transcriptional regulator; Cd00093, HTH_XRE, helix-turn-helix XRE-family like proteins.	0.476
smi_1730	grpE-2	smi_1730	smi_1728	HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.	grpE domain protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	0.978
smi_1730	smi_1727	smi_1730	smi_1727	HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.	Conserved hypothetical protein.	0.727
smi_1730	smi_1729	smi_1730	smi_1729	HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.	dnaJ domain protein; Chaperone, tetratricopeptide repeat domain, homology to DnaJ.	0.761
smi_1730	smi_1731	smi_1730	smi_1731	HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family.	Conserved hypothetical protein.	0.773