Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
smi_1742Histidine kinase; COG4585. (332 aa)    
Predicted Functional Partners:
smi_1741
Response regulator; COG2197.
 
 0.999
smi_1743
Conserved hypothetical protein; COG4758, membrane protein.
 
  
 0.956
smi_0259
DNA-binding response regulator.
 
 
 0.876
smi_1457
COG2197, response regulator of regulon involved in salavaricin-like lantibiotics.
 
 
 0.869
fni
Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
       0.716
smi_1745
Phosphomevalonate kinase; COG1577.
       0.716
smi_1746
Mevalonate pyrophosphate decarboxylase; COG3407.
       0.716
smi_1747
Mevalonate kinase; COG1577.
       0.716
smi_1740
DNA alkylation repair enzyme, truncation.
  
    0.588
smi_1622
Serine/threonine protein kinase; COG2815.
 
  
 0.570
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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