Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1745Phosphomevalonate kinase; COG1577. (335 aa)    
Predicted Functional Partners:
smi_1746
Mevalonate pyrophosphate decarboxylase; COG3407.
 
 
 0.999
smi_1747
Mevalonate kinase; COG1577.
 
  
 0.998
fni
Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
  
 0.989
smi_1619
3-hydroxy-3-methylglutaryl CoA synthase; COG3425.
 
  
 0.928
smi_1618
3-hydroxy-3-methylglutaryl-coenzyme a reductase; COG1257; Belongs to the HMG-CoA reductase family.
 
 
 0.879
smi_1742
Histidine kinase; COG4585.
       0.716
smi_1743
Conserved hypothetical protein; COG4758, membrane protein.
       0.716
smi_1741
Response regulator; COG2197.
       0.698
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
      
 0.512
cbpF
Choline binding protein CbpF; COG5263, glucan-binding domain (YG repeat).
       0.501
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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