Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smi_1755Conserved hypothetical protein; Belongs to the UPF0398 family. (175 aa)    
Predicted Functional Partners:
gpsB
Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
 
   
 0.806
recU
Recombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family.
 
    0.794
pbp1a
Penicillin-binding protein 1a.
 
     0.775
smi_1300
Conserved hypothetical protein; Cd00189, tetratricopeptide repeat domain.
  
     0.747
smi_0362
ABC transporter membrane-spanning permease.
  
     0.711
smi_0213
Conserved hypothetical protein.
  
     0.655
smi_1080
Conserved hypothetical protein; Belongs to the SprT family.
  
     0.592
smi_0753
Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily; COG1368.
  
     0.577
prsA-2
Peptidylprolyl isomerase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins.
  
     0.526
smi_0952
Conserved hypothetical protein; Belongs to the UPF0346 family.
  
     0.510
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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