Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pbp1aPenicillin-binding protein 1a. (726 aa)    
Predicted Functional Partners:
pbp2x
Penicillin-binding protein 2X.
 
 
 0.996
pbp2B
Penicillin-binding protein 2B.
 
 
 0.995
gpsB
Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation.
 
 
 
 0.974
pbp3
D-alanyl-D-alanine carboxypeptidase, penicillin-binding protein 3; Belongs to the peptidase S11 family.
  
 
 0.970
pbp2a
Penicillin-binding protein 2A.
  
  
0.937
recU
Recombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family.
 
  
 0.921
vanYb
Carboxypeptidase; Penicillin-insensitive metallo-DD-carboxypeptidase.
     
 0.903
rodA
Pfam01098, FTSW_RODA_SPOVE, cell cycle protein; Belongs to the SEDS family.
  
 
 
 0.894
mreC
Cell shape determining protein MreC; Involved in formation and maintenance of cell shape.
  
 
 0.830
ftsW
Cell division protein FtsW; Belongs to the SEDS family.
  
 
 
 0.778
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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