Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_1812Conserved hypothetical protein. (282 aa)    
Predicted Functional Partners:
smi_1811
Conserved hypothetical protein.
 
     0.955
cbiQ
ABC transporter permease; COG0619, CbiQ, ABC-type cobalt transport system.
 
     0.903
cbiO
ABC transporter ATP-binding protein-cobalt transport; COG1122, CbiO, ABC-type cobalt transport system.
 
     0.889
trkA2
Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.
       0.511
trkG2
Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.
       0.511
smi_1941
ABC transporter permease; COG 2011, metal ion transport.
       0.461
metN
ABC transporter ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
       0.461
smi_1943
Deacylase; COG0624, acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase /and related deacylases; peptidase family M20. This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification. Family M20 are glutamate carboxypeptidases.
       0.461
sstT
Predicted Na+/serine symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.
       0.453
smi_1940
Conserved hypothetical protein.
       0.445
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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