trkA2 protein (Streptococcus mitis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

trkA2

Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component. (449 aa)

Predicted Functional Partners:

trkG2

0.992

trkG1

0.681

cspR

0.561

smi_1624

0.536

smi_0670

0.524

smi_1812

0.511

smi_1811

0.489

Your Current Organism:

Streptococcus mitis

NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cspR	trkA2	smi_1808	smi_1813	rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	0.561
cspR	trkG2	smi_1808	smi_1814	rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	0.570
smi_0670	trkA2	smi_0670	smi_1813	Ferredoxin; COG1141.	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	0.524
smi_1624	trkA2	smi_1624	smi_1813	rRNA-specific 5-methylcytidine transferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	0.536
smi_1811	smi_1812	smi_1811	smi_1812	Conserved hypothetical protein.	Conserved hypothetical protein.	0.955
smi_1811	trkA2	smi_1811	smi_1813	Conserved hypothetical protein.	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	0.489
smi_1811	trkG2	smi_1811	smi_1814	Conserved hypothetical protein.	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	0.489
smi_1812	smi_1811	smi_1812	smi_1811	Conserved hypothetical protein.	Conserved hypothetical protein.	0.955
smi_1812	trkA2	smi_1812	smi_1813	Conserved hypothetical protein.	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	0.511
smi_1812	trkG2	smi_1812	smi_1814	Conserved hypothetical protein.	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	0.511
trkA2	cspR	smi_1813	smi_1808	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.	0.561
trkA2	smi_0670	smi_1813	smi_0670	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	Ferredoxin; COG1141.	0.524
trkA2	smi_1624	smi_1813	smi_1624	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	rRNA-specific 5-methylcytidine transferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.	0.536
trkA2	smi_1811	smi_1813	smi_1811	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	Conserved hypothetical protein.	0.489
trkA2	smi_1812	smi_1813	smi_1812	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	Conserved hypothetical protein.	0.511
trkA2	trkG1	smi_1813	smi_0088	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	0.681
trkA2	trkG2	smi_1813	smi_1814	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	0.992
trkG1	trkA2	smi_0088	smi_1813	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	Potassium uptake protein; COG0569, TrkA, K+ transport system, NAD-binding component.	0.681
trkG2	cspR	smi_1814	smi_1808	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.	0.570
trkG2	smi_1811	smi_1814	smi_1811	Potassium uptake protein; COG0168, TrkG, Trk-type K+ transport system, membrane component.	Conserved hypothetical protein.	0.489