Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
smi_1950Transcriptional regulator; Cd00093, Helix-turn-helix XRE-family like proteins. (287 aa)    
Predicted Functional Partners:
smi_1953
Molecular chaperone; COG1214, inactive homolog of metal-dependent proteases.
  
    0.563
smi_1952
Acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.
  
    0.544
tsaD
Metal-dependent protease; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
       0.543
smi_0857
4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein; Intracellular protease/amidase.
      
 0.524
smi_1949
Metal-dependent CAAX amino terminal membrane protease family protein; Pfam02517.
       0.510
smi_1811
Conserved hypothetical protein.
  
     0.509
smi_0847
Conserved hypothetical protein; COG1247, sortase and related acyltransferases.
   
    0.499
cbiQ
ABC transporter permease; COG0619, CbiQ, ABC-type cobalt transport system.
  
    0.467
cbiO
ABC transporter ATP-binding protein-cobalt transport; COG1122, CbiO, ABC-type cobalt transport system.
  
     0.438
sagA
General stress protein GSP-781 amidase; Pfam05257, CHAP domain. This domain corresponds to an amidase function.
  
     0.429
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.