Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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adcCABC zinc transporter ATP-binding protein; COG1121, ABC-type Mn/Zn transport, ATPase component. (234 aa)    
Predicted Functional Partners:
smi_1143
Metal binding protein, AcdA-family; These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion, signal peptide type I, excreted protein; Belongs to the bacterial solute-binding protein 9 family.
 
 
 0.999
adcA
ABC zinc transporter, metal-binding lipoprotein; Cd01017, metal binding protein AcdA; Belongs to the bacterial solute-binding protein 9 family.
 
 
 0.999
adcB
ABC zinc transporter permease; COG1108, ABC-type Mn2+/Zn2+ transport systems.
 
 0.999
adcR
Zn(2+)-responsive AdcR transcriptional repressor; Pfam01047, MarR family.
  
  
 0.999
psaA
Manganese ABC transporter substrate-binding lipoprotein (Pneumococcal surface adhesin A; Belongs to the bacterial solute-binding protein 9 family.
 
  
 0.939
psaC
ABC transporter membrane-spanning permease-manganese transport.
 
 
 0.919
dltA
D-alanine:Dcp ligase Dcl; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP-bi [...]
  
    0.531
dltC
D-alanyl carrier protein DCP; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
  
    0.521
dltD
Membrane-associated protein dltD; Facilitates D-alanine ligation to DCP by binding Dcl and Dcp.
       0.519
dltB
Transport protein DltB; Could be involved in the transport of activated D-alanine through the membrane.
       0.505
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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