Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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dltDMembrane-associated protein dltD; Facilitates D-alanine ligation to DCP by binding Dcl and Dcp. (422 aa)    
Predicted Functional Partners:
dltC
D-alanyl carrier protein DCP; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
 
 
 0.999
dltB
Transport protein DltB; Could be involved in the transport of activated D-alanine through the membrane.
 
 
 0.999
dltA
D-alanine:Dcp ligase Dcl; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP-bi [...]
 
 
 0.999
smi_0513
Conserved hypothetical protein; COG3307, RfaL, lipid A core - O-antigen ligase and related enzymes.
     
  0.900
smi_0766
Transcriptional regulator; COG1316, LytR.
     
  0.900
smi_1841
Transcriptional regulator; COG1316, LytR, one TM helix predicted.
     
  0.900
adcR
Zn(2+)-responsive AdcR transcriptional repressor; Pfam01047, MarR family.
 
     0.619
ftsH
Cell-division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
   
  
 0.531
adcB
ABC zinc transporter permease; COG1108, ABC-type Mn2+/Zn2+ transport systems.
       0.519
adcC
ABC zinc transporter ATP-binding protein; COG1121, ABC-type Mn/Zn transport, ATPase component.
       0.519
Your Current Organism:
Streptococcus mitis
NCBI taxonomy Id: 365659
Other names: S. mitis B6, Streptococcus mitis B6, Streptococcus mitis str. B6, Streptococcus mitis strain B6
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