| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MecA | clpC | smi_0772 | smi_2045 | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.813 |
| MecA | clpP | smi_0772 | smi_1417 | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.670 |
| MecA | clpX | smi_0772 | smi_1559 | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.528 |
| clpC | MecA | smi_2045 | smi_0772 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.813 |
| clpC | clpP | smi_2045 | smi_1417 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.966 |
| clpC | clpX | smi_2045 | smi_1559 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.800 |
| clpC | ctsR | smi_2045 | smi_2046 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Pfam05848, firmicute transcriptional repressor of class III stress genes (CtsR); Belongs to the CtsR family. | 0.952 |
| clpC | dnaJ | smi_2045 | smi_0357 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | dnaJ protein, Heat-shock protein (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depende [...] | 0.722 |
| clpC | dnaK | smi_2045 | smi_0355 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Class I heat-shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.812 |
| clpC | groEL | smi_2045 | smi_0482 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | CH60_SMI 60 kDa chaperonin (protein Cpn60); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.619 |
| clpC | groES | smi_2045 | smi_0481 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | CH10_SMI 10 kDa chaperonin (protein Cpn10); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.737 |
| clpC | smi_1730 | smi_2045 | smi_1730 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | HSP70 family protein; Chaperone, homology to DnaK, COG0443; Belongs to the heat shock protein 70 family. | 0.720 |
| clpC | smi_2042 | smi_2045 | smi_2042 | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | Conserved hypothetical protein. | 0.679 |
| clpP | MecA | smi_1417 | smi_0772 | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | MecA protein; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.670 |
| clpP | clpC | smi_1417 | smi_2045 | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | COG0542, ClpA, ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.966 |
| clpP | clpX | smi_1417 | smi_1559 | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.999 |
| clpP | ctsR | smi_1417 | smi_2046 | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Pfam05848, firmicute transcriptional repressor of class III stress genes (CtsR); Belongs to the CtsR family. | 0.693 |
| clpP | dnaJ | smi_1417 | smi_0357 | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | dnaJ protein, Heat-shock protein (activation of DnaK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depende [...] | 0.636 |
| clpP | dnaK | smi_1417 | smi_0355 | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Class I heat-shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.700 |
| clpP | groEL | smi_1417 | smi_0482 | ATP-dependent CLP protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | CH60_SMI 60 kDa chaperonin (protein Cpn60); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.861 |
