STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Smed_3209Protein of unknown function DUF299; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (273 aa)    
Predicted Functional Partners:
Smed_0548
TIGRFAM: pyruvate, phosphate dikinase; PFAM: PEP-utilizing protein; pyruvate phosphate dikinase PEP/pyruvate-binding; PEP-utilising protein mobile region; KEGG: sme:SMc00025 putative pyruvate phosphate dikinase protein; Belongs to the PEP-utilizing enzyme family.
 
  
 0.749
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
 
     0.741
Smed_3210
Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily.
       0.704
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
       0.704
dnaQ
DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.
       0.551
Smed_1046
Putative signal-transduction protein with CBS domains; PFAM: CBS domain containing protein; KEGG: sme:SMc01002 hypothetical protein.
  
  
 0.527
Smed_1094
PFAM: aminotransferase class IV; KEGG: sme:SMc01047 putative aminotransferase protein.
  
   
 0.519
glyS
TIGRFAM: glycyl-tRNA synthetase, beta subunit; KEGG: sme:SMc00851 probable glycyl-tRNA synthetase beta chain protein.
 
    0.449
Smed_0224
Transcriptional regulator, DeoR family; PFAM: regulatory protein DeoR; regulatory protein DeoR; KEGG: sme:SMc02323 putative transcription regulator protein.
     
 0.433
Smed_2151
Transcriptional regulator, DeoR family; PFAM: regulatory protein DeoR; regulatory protein ArsR; Helix-turn-helix type 11 domain protein; regulatory protein DeoR; KEGG: sme:SMc01615 putative transcription regulator protein.
     
 0.433
Your Current Organism:
Sinorhizobium medicae
NCBI taxonomy Id: 366394
Other names: Ensifer medicae WSM419, S. medicae WSM419, Sinorhizobium medicae WSM419
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.