node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHE33256.1 | SHE44625.1 | SAMN05444339_10172 | SAMN05444339_101386 | D-alanine transaminase. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.952 |
SHE33256.1 | SHE50991.1 | SAMN05444339_10172 | SAMN05444339_101577 | D-alanine transaminase. | Acetolactate synthase, small subunit. | 0.589 |
SHE33256.1 | SHE90035.1 | SAMN05444339_10172 | SAMN05444339_102396 | D-alanine transaminase. | Branched-chain amino acid aminotransferase. | 0.741 |
SHE33256.1 | SHF06299.1 | SAMN05444339_10172 | SAMN05444339_103160 | D-alanine transaminase. | Branched-chain amino acid aminotransferase. | 0.884 |
SHE33256.1 | ilvE | SAMN05444339_10172 | SAMN05444339_103281 | D-alanine transaminase. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.752 |
SHE44625.1 | SHE33256.1 | SAMN05444339_101386 | SAMN05444339_10172 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | D-alanine transaminase. | 0.952 |
SHE44625.1 | SHE50991.1 | SAMN05444339_101386 | SAMN05444339_101577 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase, small subunit. | 0.979 |
SHE44625.1 | SHE90035.1 | SAMN05444339_101386 | SAMN05444339_102396 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase. | 0.911 |
SHE44625.1 | SHF06299.1 | SAMN05444339_101386 | SAMN05444339_103160 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched-chain amino acid aminotransferase. | 0.955 |
SHE44625.1 | SHF37244.1 | SAMN05444339_101386 | SAMN05444339_105228 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.930 |
SHE44625.1 | ilvC | SAMN05444339_101386 | SAMN05444339_10557 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.916 |
SHE44625.1 | ilvE | SAMN05444339_101386 | SAMN05444339_103281 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Branched chain amino acid aminotransferase apoenzyme; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.911 |
SHE44625.1 | leuB | SAMN05444339_101386 | SAMN05444339_103106 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.923 |
SHE44625.1 | leuC | SAMN05444339_101386 | SAMN05444339_103102 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.987 |
SHE44625.1 | leuD | SAMN05444339_101386 | SAMN05444339_103103 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.987 |
SHE50991.1 | SHE33256.1 | SAMN05444339_101577 | SAMN05444339_10172 | Acetolactate synthase, small subunit. | D-alanine transaminase. | 0.589 |
SHE50991.1 | SHE44625.1 | SAMN05444339_101577 | SAMN05444339_101386 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.979 |
SHE50991.1 | SHE90035.1 | SAMN05444339_101577 | SAMN05444339_102396 | Acetolactate synthase, small subunit. | Branched-chain amino acid aminotransferase. | 0.630 |
SHE50991.1 | SHF06299.1 | SAMN05444339_101577 | SAMN05444339_103160 | Acetolactate synthase, small subunit. | Branched-chain amino acid aminotransferase. | 0.629 |
SHE50991.1 | ilvC | SAMN05444339_101577 | SAMN05444339_10557 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |