node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHE42888.1 | SHE56475.1 | SAMN05444339_101344 | SAMN05444339_101740 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.998 |
SHE42888.1 | SHE65595.1 | SAMN05444339_101344 | SAMN05444339_1011000 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dimethylsulfoniopropionate demethylase; Belongs to the GcvT family. | 0.872 |
SHE42888.1 | fhs | SAMN05444339_101344 | SAMN05444339_11114 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.916 |
SHE42888.1 | folD | SAMN05444339_101344 | SAMN05444339_11113 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.474 |
SHE42888.1 | glyA | SAMN05444339_101344 | SAMN05444339_105161 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.755 |
SHE42888.1 | glyA-2 | SAMN05444339_101344 | SAMN05444339_11111 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.755 |
SHE42888.1 | purU | SAMN05444339_101344 | SAMN05444339_102451 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.854 |
SHE56475.1 | SHE42888.1 | SAMN05444339_101740 | SAMN05444339_101344 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.998 |
SHE56475.1 | SHE65595.1 | SAMN05444339_101740 | SAMN05444339_1011000 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Dimethylsulfoniopropionate demethylase; Belongs to the GcvT family. | 0.881 |
SHE56475.1 | fhs | SAMN05444339_101740 | SAMN05444339_11114 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.941 |
SHE56475.1 | folD | SAMN05444339_101740 | SAMN05444339_11113 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.872 |
SHE56475.1 | glyA | SAMN05444339_101740 | SAMN05444339_105161 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.755 |
SHE56475.1 | glyA-2 | SAMN05444339_101740 | SAMN05444339_11111 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.755 |
SHE56475.1 | purN | SAMN05444339_101740 | SAMN05444339_101748 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.875 |
SHE56475.1 | purU | SAMN05444339_101740 | SAMN05444339_102451 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.881 |
SHE65595.1 | SHE42888.1 | SAMN05444339_1011000 | SAMN05444339_101344 | Dimethylsulfoniopropionate demethylase; Belongs to the GcvT family. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.872 |
SHE65595.1 | SHE56475.1 | SAMN05444339_1011000 | SAMN05444339_101740 | Dimethylsulfoniopropionate demethylase; Belongs to the GcvT family. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.881 |
SHE65595.1 | fhs | SAMN05444339_1011000 | SAMN05444339_11114 | Dimethylsulfoniopropionate demethylase; Belongs to the GcvT family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.899 |
SHE65595.1 | folD | SAMN05444339_1011000 | SAMN05444339_11113 | Dimethylsulfoniopropionate demethylase; Belongs to the GcvT family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.938 |
SHE65595.1 | glyA | SAMN05444339_1011000 | SAMN05444339_105161 | Dimethylsulfoniopropionate demethylase; Belongs to the GcvT family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.882 |