node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Caul_2001 | Caul_3387 | Caul_2001 | Caul_3387 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.993 |
Caul_2001 | Caul_3409 | Caul_2001 | Caul_3409 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | KEGG: ccr:CC_2140 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.915 |
Caul_2001 | Caul_4387 | Caul_2001 | Caul_4387 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: ccr:CC_3355 glycine cleavage system T protein. | 0.913 |
Caul_2001 | Caul_4979 | Caul_2001 | Caul_4979 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | KEGG: ccr:CC_3541 bifunctional protein (dihydrofolate synthase / folylpolyglutamate synthase); TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein. | 0.827 |
Caul_2001 | dut | Caul_2001 | Caul_5069 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.956 |
Caul_2001 | folD | Caul_2001 | Caul_1714 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
Caul_2001 | glyA | Caul_2001 | Caul_3047 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.922 |
Caul_2001 | surE | Caul_2001 | Caul_3114 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.913 |
Caul_2001 | thyA | Caul_2001 | Caul_3385 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.928 |
Caul_2001 | tmk | Caul_2001 | Caul_2699 | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.927 |
Caul_3387 | Caul_2001 | Caul_3387 | Caul_2001 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | 0.993 |
Caul_3387 | Caul_4387 | Caul_3387 | Caul_4387 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: ccr:CC_3355 glycine cleavage system T protein. | 0.916 |
Caul_3387 | Caul_4979 | Caul_3387 | Caul_4979 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | KEGG: ccr:CC_3541 bifunctional protein (dihydrofolate synthase / folylpolyglutamate synthase); TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein. | 0.931 |
Caul_3387 | glyA | Caul_3387 | Caul_3047 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
Caul_3387 | thyA | Caul_3387 | Caul_3385 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
Caul_3387 | tmk | Caul_3387 | Caul_2699 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.408 |
Caul_3409 | Caul_2001 | Caul_3409 | Caul_2001 | KEGG: ccr:CC_2140 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: thymidylate synthase; KEGG: bxe:Bxe_A0214 putative thymidylate synthase. | 0.915 |
Caul_3409 | Caul_4387 | Caul_3409 | Caul_4387 | KEGG: ccr:CC_2140 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | TIGRFAM: glycine cleavage system T protein; PFAM: glycine cleavage T protein (aminomethyl transferase); Glycine cleavage T-protein barrel; KEGG: ccr:CC_3355 glycine cleavage system T protein. | 0.922 |
Caul_3409 | folD | Caul_3409 | Caul_1714 | KEGG: ccr:CC_2140 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.938 |
Caul_3409 | glyA | Caul_3409 | Caul_3047 | KEGG: ccr:CC_2140 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |