| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Caul_0172 | murI | Caul_0172 | Caul_4875 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.919 |
| Caul_1044 | Caul_2853 | Caul_1044 | Caul_2853 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | 0.940 |
| Caul_1044 | Caul_3944 | Caul_1044 | Caul_3944 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Glutamate--putrescine ligase; PFAM: glutamine synthetase catalytic region; KEGG: ccr:CC_3130 glutamine synthetase family protein. | 0.940 |
| Caul_1044 | Caul_3952 | Caul_1044 | Caul_3952 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | PFAM: glutamine synthetase catalytic region; KEGG: ccr:CC_3138 glutamine synthetase family protein. | 0.940 |
| Caul_1044 | Caul_4950 | Caul_1044 | Caul_4950 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: ccr:CC_3607 glutamate synthase, large subunit. | 0.952 |
| Caul_1044 | glsA | Caul_1044 | Caul_4564 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | PFAM: Glutaminase, core; KEGG: ccr:CC_0276 glutaminase A; Belongs to the glutaminase family. | 0.915 |
| Caul_1044 | murI | Caul_1044 | Caul_4875 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.879 |
| Caul_1044 | purQ | Caul_1044 | Caul_3449 | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.902 |
| Caul_1127 | glsA | Caul_1127 | Caul_4564 | PFAM: protein of unknown function DUF1611; KEGG: sal:Sala_1462 protein of unknown function DUF1611. | PFAM: Glutaminase, core; KEGG: ccr:CC_0276 glutaminase A; Belongs to the glutaminase family. | 0.900 |
| Caul_1127 | murD | Caul_1127 | Caul_3669 | PFAM: protein of unknown function DUF1611; KEGG: sal:Sala_1462 protein of unknown function DUF1611. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.900 |
| Caul_1127 | murI | Caul_1127 | Caul_4875 | PFAM: protein of unknown function DUF1611; KEGG: sal:Sala_1462 protein of unknown function DUF1611. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.900 |
| Caul_1127 | purQ | Caul_1127 | Caul_3449 | PFAM: protein of unknown function DUF1611; KEGG: sal:Sala_1462 protein of unknown function DUF1611. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
| Caul_2853 | Caul_1044 | Caul_2853 | Caul_1044 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.940 |
| Caul_2853 | Caul_3944 | Caul_2853 | Caul_3944 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | Glutamate--putrescine ligase; PFAM: glutamine synthetase catalytic region; KEGG: ccr:CC_3130 glutamine synthetase family protein. | 0.916 |
| Caul_2853 | Caul_3952 | Caul_2853 | Caul_3952 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | PFAM: glutamine synthetase catalytic region; KEGG: ccr:CC_3138 glutamine synthetase family protein. | 0.916 |
| Caul_2853 | Caul_4950 | Caul_2853 | Caul_4950 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | PFAM: glutamine amidotransferase class-II; glutamate synthase alpha subunit domain protein; ferredoxin-dependent glutamate synthase; glutamate synthase; KEGG: ccr:CC_3607 glutamate synthase, large subunit. | 0.962 |
| Caul_2853 | glsA | Caul_2853 | Caul_4564 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | PFAM: Glutaminase, core; KEGG: ccr:CC_0276 glutaminase A; Belongs to the glutaminase family. | 0.912 |
| Caul_2853 | murI | Caul_2853 | Caul_4875 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.830 |
| Caul_2853 | purQ | Caul_2853 | Caul_3449 | TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase catalytic region; glutamine synthetase beta-Grasp; KEGG: ccr:CC_1969 glutamine synthetase, class I. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.908 |
| Caul_3944 | Caul_1044 | Caul_3944 | Caul_1044 | Glutamate--putrescine ligase; PFAM: glutamine synthetase catalytic region; KEGG: ccr:CC_3130 glutamine synthetase family protein. | Delta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. | 0.940 |