node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Caul_4679 | Caul_4680 | Caul_4679 | Caul_4680 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | 0.999 |
Caul_4679 | hisA | Caul_4679 | Caul_5043 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: ccr:CC_3736 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.991 |
Caul_4679 | hisB | Caul_4679 | Caul_5045 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: ccr:CC_3734 imidazoleglycerol-phosphate dehydratase. | 0.993 |
Caul_4679 | hisC | Caul_4679 | Caul_3228 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: ccr:CC_2223 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.880 |
Caul_4679 | hisC-2 | Caul_4679 | Caul_3654 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | PFAM: aminotransferase class I and II; KEGG: ccr:CC_2534 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.891 |
Caul_4679 | hisD | Caul_4679 | Caul_3588 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.993 |
Caul_4679 | hisE | Caul_4679 | Caul_5041 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: ccr:CC_3738 phosphoribosyl-ATP pyrophosphatase. | 0.998 |
Caul_4679 | hisF | Caul_4679 | Caul_5042 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.992 |
Caul_4679 | hisH | Caul_4679 | Caul_5044 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.993 |
Caul_4679 | hisI | Caul_4679 | Caul_0351 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.993 |
Caul_4680 | Caul_4679 | Caul_4680 | Caul_4679 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.999 |
Caul_4680 | hisA | Caul_4680 | Caul_5043 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: histidine biosynthesis protein; KEGG: ccr:CC_3736 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.931 |
Caul_4680 | hisB | Caul_4680 | Caul_5045 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | PFAM: imidazoleglycerol-phosphate dehydratase; KEGG: ccr:CC_3734 imidazoleglycerol-phosphate dehydratase. | 0.948 |
Caul_4680 | hisC | Caul_4680 | Caul_3228 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: ccr:CC_2223 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.646 |
Caul_4680 | hisC-2 | Caul_4680 | Caul_3654 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | PFAM: aminotransferase class I and II; KEGG: ccr:CC_2534 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.646 |
Caul_4680 | hisD | Caul_4680 | Caul_3588 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.938 |
Caul_4680 | hisE | Caul_4680 | Caul_5041 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-ATP pyrophosphohydrolase; KEGG: ccr:CC_3738 phosphoribosyl-ATP pyrophosphatase. | 0.988 |
Caul_4680 | hisF | Caul_4680 | Caul_5042 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.934 |
Caul_4680 | hisH | Caul_4680 | Caul_5044 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.911 |
Caul_4680 | hisI | Caul_4680 | Caul_0351 | PFAM: tRNA synthetase class II (G H P and S); KEGG: ccr:CC_3512 ATP phosphoribosyltransferase regulatory subunit. | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.910 |