| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQR93049.1 | AQR93050.1 | CLSAP_03240 | CLSAP_03250 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Hypothetical protein. | 0.651 |
| AQR93049.1 | fchA | CLSAP_03240 | CLSAP_10800 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methenyltetrahydrofolate cyclohydrolase. | 0.982 |
| AQR93049.1 | fhs | CLSAP_03240 | CLSAP_01270 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.767 |
| AQR93049.1 | folD | CLSAP_03240 | CLSAP_24920 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.985 |
| AQR93049.1 | gluP_1 | CLSAP_03240 | CLSAP_38480 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Rhomboid protease GluP. | 0.670 |
| AQR93049.1 | gluP_2 | CLSAP_03240 | CLSAP_43770 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Rhomboid protease GluP. | 0.723 |
| AQR93049.1 | glyA | CLSAP_03240 | CLSAP_25620 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.690 |
| AQR93049.1 | hndA | CLSAP_03240 | CLSAP_41420 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | NADP-reducing hydrogenase subunit HndA. | 0.576 |
| AQR93049.1 | pheT | CLSAP_03240 | CLSAP_24400 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. | 0.575 |
| AQR93049.1 | purN | CLSAP_03240 | CLSAP_11550 | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.927 |
| AQR93050.1 | AQR93049.1 | CLSAP_03250 | CLSAP_03240 | Hypothetical protein. | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.651 |
| fchA | AQR93049.1 | CLSAP_10800 | CLSAP_03240 | Methenyltetrahydrofolate cyclohydrolase. | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.982 |
| fchA | fhs | CLSAP_10800 | CLSAP_01270 | Methenyltetrahydrofolate cyclohydrolase. | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.997 |
| fchA | folD | CLSAP_10800 | CLSAP_24920 | Methenyltetrahydrofolate cyclohydrolase. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.996 |
| fchA | purN | CLSAP_10800 | CLSAP_11550 | Methenyltetrahydrofolate cyclohydrolase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.967 |
| fhs | AQR93049.1 | CLSAP_01270 | CLSAP_03240 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.767 |
| fhs | fchA | CLSAP_01270 | CLSAP_10800 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase. | 0.997 |
| fhs | folD | CLSAP_01270 | CLSAP_24920 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional protein FolD protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.999 |
| fhs | glyA | CLSAP_01270 | CLSAP_25620 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.991 |
| fhs | purN | CLSAP_01270 | CLSAP_11550 | Formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.992 |