| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AQR93174.1 | AQR93478.1 | CLSAP_04510 | CLSAP_07840 | Putative redox-active protein. | Hypothetical protein. | 0.513 |
| AQR93174.1 | alkA | CLSAP_04510 | CLSAP_04520 | Putative redox-active protein. | DNA-3-methyladenine glycosylase. | 0.770 |
| AQR93174.1 | aroA | CLSAP_04510 | CLSAP_50550 | Putative redox-active protein. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.494 |
| AQR93174.1 | cdr_2 | CLSAP_04510 | CLSAP_30790 | Putative redox-active protein. | Coenzyme A disulfide reductase; Belongs to the sulfur carrier protein TusA family. | 0.561 |
| AQR93174.1 | clpX | CLSAP_04510 | CLSAP_15090 | Putative redox-active protein. | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.590 |
| AQR93174.1 | glyA | CLSAP_04510 | CLSAP_25620 | Putative redox-active protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.537 |
| AQR93174.1 | ribD | CLSAP_04510 | CLSAP_13290 | Putative redox-active protein. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.771 |
| AQR93174.1 | tdk | CLSAP_04510 | CLSAP_06100 | Putative redox-active protein. | Thymidine kinase. | 0.537 |
| AQR93174.1 | thyA1 | CLSAP_04510 | CLSAP_53730 | Putative redox-active protein. | Thymidylate synthase 1; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.797 |
| AQR93174.1 | tmk | CLSAP_04510 | CLSAP_01480 | Putative redox-active protein. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.514 |
| AQR93478.1 | AQR93174.1 | CLSAP_07840 | CLSAP_04510 | Hypothetical protein. | Putative redox-active protein. | 0.513 |
| alkA | AQR93174.1 | CLSAP_04520 | CLSAP_04510 | DNA-3-methyladenine glycosylase. | Putative redox-active protein. | 0.770 |
| aroA | AQR93174.1 | CLSAP_50550 | CLSAP_04510 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Putative redox-active protein. | 0.494 |
| aroA | glyA | CLSAP_50550 | CLSAP_25620 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.411 |
| cdr_2 | AQR93174.1 | CLSAP_30790 | CLSAP_04510 | Coenzyme A disulfide reductase; Belongs to the sulfur carrier protein TusA family. | Putative redox-active protein. | 0.561 |
| cdr_2 | glyA | CLSAP_30790 | CLSAP_25620 | Coenzyme A disulfide reductase; Belongs to the sulfur carrier protein TusA family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.722 |
| clpX | AQR93174.1 | CLSAP_15090 | CLSAP_04510 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Putative redox-active protein. | 0.590 |
| clpX | ribD | CLSAP_15090 | CLSAP_13290 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.513 |
| clpX | thyA1 | CLSAP_15090 | CLSAP_53730 | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | Thymidylate synthase 1; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.410 |
| glyA | AQR93174.1 | CLSAP_25620 | CLSAP_04510 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative redox-active protein. | 0.537 |